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But with ED, PDE5 may possibly break down cGMP also swiftly and allow it to be more challenging for you to get or hold an erection. PDE5 inhibitors like sildenafil support slow down PDE5 mainly because it breaks down cGMP, which makes it simpler to get tough and continue to be tough.A B C D E File G H I J K L M N O P Q R S T U V W X Y Z Obtaining O